Early days in drug discovery by crystallography - personal recollections.

Protein crystallography and drug discovery: recollections of knowledge exchange between academia and industry

The development of structure-guided drug discovery is a story of knowledge exchange where new ideas originate from all parts of the research ecosystem. Dorothy Crowfoot Hodgkin obtained insulin from Boots Pure Drug Company in the 1930s and insulin crystallization was optimized in the company Novo in the 1950s, allowing the structure to be determined at Oxford University. The structure of renin ...

The Bragg legacy: early days in macromolecular crystallography.

W. H. Bragg arrived in Australia in 1886 as Head of the Mathematics and Physics Departments at the University of Adelaide. His son, W. L. Bragg, grew up in Adelaide and graduated from the Physics Department. Many years later I graduated from the same department and had the opportunity to share Lawrence Bragg's recollections of life in Adelaide. As well as touching on the 'Adelaide' connection, ...

***Removed from the Issue*** Application of Cell-Based Assay Systems for the Early Screening of Human Drug Hepatotoxicity in the Discovery Phase of Drug Development

Withdrawing of Article ''Application of Cell-Based Assay Systems for the Early Screening of Human Drug Hepatotoxicity in the Discovery Phase of Drug Development''

***Removed from the Issue*** Application of Cell-Based Assay Systems for the Early Screening of Human Drug Hepatotoxicity in the Discovery Phase of Drug Development